Dr. Sireen Gopal is a quadruple board-certified physician specializing in Physical Medicine & Rehabilitative Medicine, Pain Medicine, Neuromuscular Medicine, and Anti-Aging & Regenerative Medicine. With over two decades of clinical experience and advanced training in longevity and functional Medicine, he is passionate about helping patients restore vitality and optimize longevity through personalized, root-cause care.

Early in his career, he became fascinated by a simple but important question:
Why do two people with the same MRI or X-rays experience completely different pain, and why does pain often return even after optimal treatments such as physical therapy, injections, or surgery?

That question led to an investigation into the deeper biology of pain. His Clinical work revealed that patients with chronic joint, spine, and nerve pain often share common systemic patterns of chronic inflammation, metabolic dysfunction, impaired mitochondrial energy production, and accelerated biological aging. “It did not mean that chronic pain causes heart disease, but it means they often share the same root drivers,” he states.

Unlike most doctors, who treat pain as a structural local pain issue, Dr. Gopal addresses it as a whole-body condition. By addressing root drivers such as inflammation, metabolic health, nervous system regulation, mitochondrial optimization, and cellular energy, he can help patients achieve more durable pain relief while improving long-term healthspan and resilience.

By recognizing the shared biology and inflammatory burden underlying both chronic pain and accelerated aging, Dr. Gopal has developed a unique approach that blends cutting-edge science with practical, real-world strategies—addressing not only pain, but the fundamental hallmarks of aging to improve both healthspan and lifespan.

Inspired by his patients and his own issues with gut health, joint-related meniscal pain, and his healing journey with root cause medicine and regenerative cell therapy, he embodies a “practice what you preach” philosophy. He continues to participate in active sports and is an avid skier, tennis and soccer player.

He also leads New York Spine & Sports Rehabilitation Medicine, an interventional pain medicine, physical therapy, and regenerative medicine practice with 3 locations in the New York City area.

He co-founded MoaiNYC.com, a community dedicated to prioritizing strong, supportive, lifelong social and meaningful connections. Dr. Gopal integrates socializing with healthy lifestyle choices, defines true, unconditional friendships as a key aspect of well-being and longevity. He proudly calls NYC Home.